Memgen is developing new therapies to harness the power of the immune system to potentially cure cancer and to protect people from COVID-19 and other diseases. The Company’s pipeline products all utilize its proprietary CD40L transgene, MEM40, which has already been tested in clinical trials and has demonstrated the ability to elicit powerful, antigen-specific immune responses.
The Company’s lead cancer immunotherapy, MEM-288, was developed in collaboration with Moffitt Cancer Center. It is an oncolytic virus engineered to selectively target cancer cells and to supercharge the immune system through expression of two unique and powerful immune modulators: MEM40 and the powerful cytokine interferon beta. MEM-288 generates a strong systemic anti-tumor immune response following intra-tumoral vaccination in multiple tumors. Memgen expects to begin clinical testing with MEM-288 in advanced cancers in the current year.
Memgen's COVID-19 vaccine, MemVax, is an adjuvant designed to be used in combination with other COVID-19 vaccines to generate a strong, durable immune response. MemVax is a highly specific immune stimulant that can work with COVID-19 antigens across a range of delivery approaches. Memgen has over 100,000 doses of MemVax ready to go into clinical trials, and an active file with the US FDA. Memgen plans to soon begin clinical trials of MemVax in collaboration with other companies developing complementary COVID-19 vaccines.
Memgen's MEM-288 Preclinical Data Presented at American Association for Cancer Research (AACR) 2020 Meeting
Management Team and Board of Directors
Extensive career bridging scientific and financial expertise in life sciences. Founder and Vice Chairman of HealthCare Royalty Partners (“HCR”). MBA from Harvard Business School, an MD from SUNY Upstate College of Medicine, and a BA from Yale University.
Extensive research and industry experience in cancer immunotherapy drug discovery and development. Inventor on multiple patented technologies, including Memgen’s viral cancer immunotherapies. PhD in Biomedical Sciences from the University of California San Diego.
Chairman of the Board
Dr. Coates is the founder and lead investor in Memgen. MBA and PhD in Finance, Accounting, and Economics from the University of Chicago Graduate School of Business.
Chief Financial Officer of Tracon Pharmaceuticals 2014-18 where she oversaw Tracon’s $41 million IPO and subsequent financings totaling over $100 million. Previous experience includes senior accounting positions at NuVasive and Orexigen Therapeutics and various CFO/accounting consulting roles.
Vice President and Head of Corporate Development at Retrophin, a billion-dollar market cap biopharmaceutical company. Currently serves as a strategic advisor to Primmune, a preclinical-stage immune-oncology company and previously served as Chief Business Officer of Tracon Pharmaceuticals.
Chief Investment Officer, Chief Financial Officer, and Chief Risk Officer with Assurant, Inc. a NYSE-traded insurance company, over twenty-three years. MBA from the University of Chicago Graduate School of Business and a BS in Economics from the University of Pennsylvania Wharton School.
Scientific Advisory Board
One of the pioneers and leaders of the immunotherapy revolution in clinical oncology. Dr. Antonia has been a principal investigator on many of the most important clinical trials of checkpoint inhibitors in lung cancer. Dr. Antonia most recently was Chairman of the Department of Thoracic Oncology at Moffitt Cancer Center. He serves on the clinical development advisory boards of several major pharmaceutical companies.
Recognized leader in the use of gene transfer to augment the immune response to human tumors using vaccines and adoptive transfer of genetically modified T cells. Dr. Brenner has coauthored more than three hundred publications that have been cited thousands of times. Dr. Brenner has previously served as President of both the International Society for Cell Therapy (ISCT) and American Society for Gene Therapy (ASGT).
Senior Member and Professor in the Departments of Immunology and Thoracic Oncology at the Moffitt Cancer Center. Dr. Beg has been at the forefront of immunology research with numerous publications to his credit. Dr. Beg leads the immunology group at Moffitt’s Lung Cancer Center of Excellence and actively serves on NIH study sections and journal editorial boards.
Assistant Professor Department of Melanoma Medical Oncology. Dr. Diab is leading multiple clinical trials involving novel immune modulator agents and has co-authored over thirty scientific publications and abstracts. Reviewer for the Journal of Immunotherapy and the Journal of the American Society of Hematology. In addition, he is leading a program for Interventional Immunotherapy that was established to develop intratumoral therapies designed to improve clinical outcomes.
World-renowned virologist and vaccinologist. Dr. Monath has developed multiple innovative vaccines, including Ebola Zaire, dengue, and C. difficile, many of which are now licensed and commercialized. He was a partner at Kleiner Perkins and has been CSO and CMO of several biotechnology companies. He has served in leading roles at the CDC and USAMRIID. He is a past president of the American Society of Tropical Medicine and Hygiene, and an elected Fellow of the Society.
Memgen’s CD40 Ligand – The basis of our approach
The CD40-CD40L system is one of the body's most powerful immune regulatory systems
- Activates the body’s entire immune armamentarium: innate immune system, cellular and humoral immunity
- Although many have tried, only Memgen has so far been able to translate the body’s CD40 ligand into a patented, safe and effective biological
Memgen’s proprietary CD40L transgene, MEM40, harnesses this powerful system
- Already tested in humans – broad-based immune stimulation with acceptable safety and modest toxicity
- Indispensable component of our armed oncolytic viruses (OV)
- Broad-based immune stimulation could make MEM40 a valuable addition to other COVID-19 vaccines
- MEM40 is especially effective in activating T-cells directed against pathogens1. T-cells are a critical component in killing cancer cells and infectious diseases
CD40-CD40L Mechanism of Action: A Pleiotropic Immune Co-Stimulatory Target for Cancer Immunotherapy
Memgen's Oncolytic Viruses (OV) – Powerful additions to the Immuno-oncology armamentarium
Memgen has developed, and has built a strong world-wide patent position, around our oncolytic viruses
- Oncolytic viruses (“onco” relates to tumors and “lytic” to dissolving a cell) are a novel class of cancer therapy with tremendous unrealized potential
Oncolytic viruses have several major advantages
- Our oncolytic viruses have been re-engineered to kill cancer cells selectively, while sparing healthy cells
- Oncolytic viruses are a type of gene therapy. Our lead product candidate, MEM-288, is an adenovirus “armed” with two powerful transgenes, including our proprietary CD40L transgene.
- Arming the OV with these genes turns the patient’s cells into tiny "drug factories" that “manufacture” proteins. Memgen’s proteins activate the patient’s immune system, especially the patient’s own cancer killing T-cells.
- MEM-288 is scheduled to enter clinical trials in 2020
MemVax: Memgen’s COVID-19 Vaccine
- MemVax was developed to be an effective immunotherapeutic vaccine against both cancer and infectious diseases
- MemVax is especially effective in activating T-cells directed against pathogens1. T-cells are a critical component to kill cancer cells and infectious diseases
Memgen’s proprietary CD40 ligand technology, MEM40, is an integral component of MemVax.
- The other major component is a non-replicating adenovirus.
The CD40-CD40 ligand system is one of the body’s most potent immune system activators.
- Activation elicits both antibody and cellular immune responses
- Because of MEM40, MemVax can be used as a vaccine adjuvant capable of synergistic combination with coronavirus vaccines
Memgen’s technology could address many challenges facing coronavirus vaccine development:
- Effectiveness in older individuals and those with compromised immune systems
- Long-term immune protection
- Prior clinical proven experience with products ready-to-go into the clinic
- MemVax plans to begin clinical testing of its COVID-19 vaccine in the second half of 2020
The Science of MemVax
Memgen announced today that Dr. Thomas Monath, a world-renowned virologist and vaccinologist, has joined the Company’s Scientific Advisory Board. The addition of Dr. Monath highlights the potential of the Company’s vaccine program as it advances its COVID-19 vaccine candidate to the clinic.
Memgen Announces Research to Be Presented at 2020 American Association of Cancer Research (AACR) Meeting
Memgen, a private biotechnology company developing novel treatments for cancer and COVID-19, announced an abstract and upcoming poster presentation at the 2020 American Association of Cancer Research (AACR) Virtual Annual Meeting II on June 22-24, 2020.
Memgen Announces Exclusive License Agreements With Moffitt Cancer Center to Develop Innovative Cancer Immunotherapies
Memgen, a private biotechnology company developing innovative immuno-oncology drugs and immune therapeutics, announced today that it has entered into technology licensing agreements with the Moffitt Cancer Center, a premier center for cancer research and care.
Memgen, a private biotechnology company developing innovative immuno-oncology drugs, announced today that its Board of Directors has appointed Gregory B. Brown, MD, as Chief Executive Officer.
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Gregory Brown, MD