VIRAL CANCER IMMUNOTHERAPY

MEM-288 Tumor Biopsies

T-Cell Infiltrating Lymphocytes


Memgen is clinically testing its lead viral immunotherapy MEM-288 for advanced non-small cell lung cancer (NSCLC). MEM-288 combines our proprietary CD40 ligand with interferon beta (IFNβ) to provide the optimum capability to generate a robust, whole-body, tumor-targeted T cell immune response. The first stage of our phase 1 clinical trial recently completed treatment of 14 advanced NSCLC patients.

Pre-Treatment
Large clusters of tumor cells

On Treatment
Widespread tumor cell death with
immune cell rich environment

  • Tumor Cells
  • T Cells
  • Dendritic Cells
  • Macrophages
  • Stroma

Safety

Only mild and transient treatment-related side effects such as injection site reactions and flu-like symptoms

Clinical Benefit

MEM-288 driven tumor shrinkage and disease control in 50% of advanced NSCL patients

Immune Activation

Induced anti-tumor immunity, including tumor specific T cell and dendritic cells, in both the tumor microenvironment and systemically throughout the body

Scientific Advisory Board

Our board provides the expertise and guidance necessary to develop our cancer immunotherapies.


View Our Scientific Advisory Board

Our Science


Memgen’s
CD40 Ligand

A patented, safe and effective biological.

Memgen is applying its expertise in immune-regulatory systems to develop a range of immunotherapies, including viral immunotherapies, cell-based immunotherapies (TILs), and infectious disease vaccine adjuvants. Our immunotherapies are designed with multimodal mechanisms of action capable of working as single agents or in combination with checkpoint inhibitors and other therapies to maximize therapeutic benefit with a desirable safety profile.

Memgen’s immunotherapies leverage the power of our proprietary clinically evaluated CD40 ligand in combination with other co-stimulatory genes. MEM-288, our lead product candidate, combines our CD40 ligand with interferon beta (IFNβ). This combination has been engineered by Memgen and Moffitt Cancer Center to provide the optimum capability to generate a robust, whole-body, tumor-targeted T cell immune response.

The combination of a highly active viral immunotherapy with two potent transgenes turns Memgen's MEM-288 into a “triple threat” attacking cancers with three discrete mechanisms.

Partnering


Memgen is actively seeking strategic partnership and business opportunities with pharmaceutical and biotechnology companies for expanded research and clinical development.

Contact Us


Memgen's Headquarters
12 Greenway Plaza
Suite 1100
Houston, TX 77046

For company inquiries and partnering please contact:
Dr. Greg Brown, Memgen’s CEO
gbrown@memgenbio.com