Memgen's Goal: Substantially improve cancer patient survival by combining ISF35 with checkpoint inhibitors


Memgen's lead product, ISF35, is a first-in-class viral cancer immunotherapy encoding an optimized version of CD40 ligand.

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About Memgen


Memgen's ISF35 viral cancer immunotherapy is being combined with checkpoint inhibitors to potentially treat a broad range of cancer types, including but not limited to lung cancer, hepatocellular carcinoma, bladder cancer, and metastatic melanoma. Phase 1 clinical trial protocols for these indications are ready for clinical collaboration.

Preclinical research evaluating Memgen’s viral cancer immunotherapy ISF35 in combination with PD-1, PD-L1, and CTLA-4 checkpoint inhibitors is guiding the clinical development of ISF35. Preclinical studies have shown that ISF35 in combination with checkpoint inhibitors cures 40% of mice with an aggressive B16 melanoma tumor, and eradicates melanoma brain metastases. These anti-tumor responses are generated through multiple immune pathways, including induction of tumor-specific CD8+ T cells, dendritic cell priming, and generation of immunostimulatory cytokines, chemokines, and immune effector molecules.

Building on this exciting research, Memgen is currently in talks for clinical trial collaborations with licensing options for the following ISF35 plus checkpoint inhibitor combination therapy trials:

  • Metastatic non-squamous non-small cell lung cancer with negative PD-L1 expression (Phase 1)
  • Hepatocellular carcinoma refractory to conventional therapies (Phase 1)
  • Advanced/metastatic bladder cancer (Phase 1)
  • Metastatic melanoma refractory to checkpoint inhibitors (Phase 1/2)

ISF35 has worldwide patent protection, qualifies for twelve years of US biologics marketing exclusivity, and has received orphan drug designation for advanced melanoma.

Leadership


Robert Coates, CEO

Robert (Bob) Coates, Ph.D., co-founded and is the majority investor in Memgen. He majored in economics at the University of Virginia, graduating in three years with a B.A. with Distinction. He received his MBA and his Ph.D. in economics, finance, and accounting from the University of Chicago’s Graduate School of Business, where he studied under several Nobel Prize winners, including Milton Friedman. Dr. Coates is also an angel investor and adviser to software and healthcare startups.

Mark Cantwell, President

Mark Cantwell, Ph.D., is a co-inventor of Memgen’s ISF35 technology. He has extensive research and industry experience in cancer immunotherapy drug discovery and development with a special focus on combination therapies. Prior to Memgen, Dr. Cantwell was employed at ADVENTRX Pharmaceuticals (currently Mast Therapeutics), a specialty pharmaceutical company, where he held the title of Vice President Research & Development in charge of product development of its oncology and infectious disease programs. Dr. Cantwell has a Ph.D. in Biomedical Sciences from the University of California San Diego where he specialized in immunotherapy and gene therapy advancements.

Science


ISF35 is a viral cancer immunotherapy encoding an optimized form of CD40 ligand. Direct intratumoral delivery of ISF35, a non-replicating adenovirus encoding CD40 ligand, activates tumor-specific T cells through immunostimulation of dendritic cells. ISF35 generates an effective anti-tumor immune response and complements checkpoint inhibitors, a class of immuno-oncology (IO) drugs that removes the brakes tumors attempt to use to stop a T cell anti-tumor immune response.

Mechanism of Action

Preclinical results for ISF35 in combination with checkpoint inhibitors have been presented at multiple scientific conferences:

Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference, September 25-28, 2016

Intratumoral CD40 activation and checkpoint blockade induces systemic anti-melanoma immunity that eradicates disseminated tumors
Manisha Singh, Christina Vianden, Adi Diab, Patrick Hwu, and Willem W. Overwijk.
University of Texas MD Anderson Cancer Center, Houston, TX

2016 AACR Annual Meeting

Induction of systemic immunity through single-site intratumoral CD40 activation and checkpoint blockade eradicates melanoma in the brain
Manisha Singh, Christina Vianden, Adi Diab, Patrick Hwu, and Willem W. Overwijk.
University of Texas MD Anderson Cancer Center, Houston, TX

30th Annual Meeting of the Society of Immunotherapy of Cancer

Induction of potent systemic anti-melanoma immunity through intratumoral CD40 activation and checkpoint blockade
Manisha Singh1, Zhimin Dai1, Hiep Khong1, Christina Vianden1, Mark Cantwell2, Willem Overwijk1
1University of Texas MD Anderson Cancer Center
2Memgen, LLC, Houston, TX

News


Nov 17, 2015
Memgen Announces Preclinical Results for ISF35 in Combination with Checkpoint Inhibitors in a Model of Metastatic Melanoma

Data was presented at the Society of Immunotherapy of Cancer’s (SITC) 30th Anniversary Annual Meeting in a poster presentation entitled Induction of Potent Systemic Anti-Melanoma Immunity through Intratumoral CD40 Activation and Checkpoint Blockade.
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Contact Us


Memgen's Headquarters
12 Greenway Plaza
Suite 1100
Houston, TX 77046

To explore business opportunities with Memgen, please contact us at bizdev@memgenbio.com.

For clinical and regulatory matters, please email us at clinreg@memgenbio.com